Can You Take Berberine and Goldenseal Together?

Dose or timing may matter

The short answer

Goldenseal naturally contains berberine. Combining with berberine supplements may lead to excessive berberine intake, potentially causing gastrointestinal distress and hypoglycemia.

How to arrange timing

Avoid combining Goldenseal with berberine supplements as they contain the same active compound. Choose one or the other.

Reference

Reference noted for this combination: Examine.com; Natural Medicines Comprehensive Database

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.