Can You Take Berberine and Dihydroberberine Together?

Dose or timing may matter

The short answer

Dihydroberberine is the active intestinal metabolite of Berberine with enhanced bioavailability. Taking both creates redundant dosing and may cause excessive blood sugar lowering.

How to arrange timing

Choose one form or the other—taking both is redundant and may increase hypoglycemia risk.

Reference

Reference noted for this combination: Journal of Pharmacology and Experimental Therapeutics 2014

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.