Can You Take Armodafinil and St. John's Wort Together?

Use extra care with this pair

The short answer

St. John's Wort is a potent inducer of CYP3A4, the primary enzyme responsible for Armodafinil metabolism. Co-administration can significantly reduce Armodafinil blood levels and diminish its efficacy.

How to arrange timing

Avoid combining St. John's Wort with Armodafinil due to significant CYP3A4 induction. If both are needed, consult a healthcare provider for dose adjustment.

Reference

Reference noted for this combination: Robertson P, et al. Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers. Clin Pharmacol Ther. 2002;71(1):46-56.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.