Can You Take Aloe Vera (Oral) and Rhubarb Root Together?

Use extra care with this pair

The short answer

Both oral Aloe Vera and Rhubarb Root (Da Huang) contain anthraquinones that are hepatotoxic at high doses. Combined use increases total anthraquinone exposure and cumulative liver toxicity risk.

How to arrange timing

Avoid prolonged concurrent use of anthraquinone-containing herbs. If used together short-term, keep doses low and monitor for digestive and liver symptoms.

Reference

Reference noted for this combination: Beuers U et al., Gastroenterology 1991; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.