Can You Take Alkaline Protease and Nattokinase Together?

Use extra care with this pair

The short answer

Both Alkaline Protease and Nattokinase possess fibrinolytic (clot-dissolving) activity. Combining them may produce an additive anticoagulant effect, increasing the risk of bleeding.

How to arrange timing

Use caution when combining Alkaline Protease with Nattokinase. Monitor for signs of excessive bleeding (easy bruising, prolonged bleeding from cuts).

Reference

Reference noted for this combination: Sumi H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto. Experientia. 1987;43(10):1110-1111.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.