Can You Take Agmatine and L-Arginine Together?

Dose or timing may matter

The short answer

Agmatine modulates nitric oxide synthesis and has hypotensive properties, while L-Arginine is the direct substrate for NO production. Combined use may produce excessive NO-mediated vasodilation and hypotension.

How to arrange timing

Research suggests agmatine may modulate arginine metabolism. Monitor blood pressure when combining.

Reference

Reference noted for this combination: Piletz JE et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today. 2013;18(17-18):880-893

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.