Can You Take Adrafinil and SAMe Together?

Use extra care with this pair

The short answer

SAMe increases serotonin availability, and Adrafinil affects monoamine neurotransmission including serotonin. This stacking may contribute to excessive serotonergic stimulation.

How to arrange timing

Exercise caution when combining SAMe and Adrafinil. Start with low doses and watch for signs of serotonin excess.

Reference

Reference noted for this combination: Dvir Y, Bhatt L, Bhatt DL. Serotonin syndrome with drug combinations. Pharmacotherapy. 2008;28(6):779-790.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.