Can You Take Adrafinil and Kratom Together?

Use extra care with this pair

The short answer

Adrafinil requires hepatic metabolism and elevates liver enzymes. Kratom causes cholestatic liver injury. Combined use may compound hepatotoxic effects through different mechanisms.

How to arrange timing

Avoid combining. Both substances individually carry hepatotoxicity concerns. Monitor liver enzymes if either is used.

Reference

Reference noted for this combination: Kapp FG et al., Drug Alcohol Depend 2011; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.