Can You Take Adrafinil and Kava Together?

Use extra care with this pair

The short answer

Adrafinil requires hepatic metabolism and may elevate liver enzymes. Kava is a well-documented hepatotoxin. This combination places significant metabolic and toxic burden on the liver.

How to arrange timing

Avoid this combination. If alertness support is needed, consider alternatives to adrafinil that do not require hepatic activation.

Reference

Reference noted for this combination: Teschke R., Ann Intern Med 2010; LiverTox (NIH/NLM)

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.