Can You Take St. John's Wort and 5-HTP Together?

Use extra care with this pair

The short answer

St. John's Wort combined with 5-HTP may cause serotonin syndrome due to additive serotonergic effects.

How to arrange timing

Do not combine. Risk of serotonin syndrome (potentially life-threatening).

Reference

Reference noted for this combination: NCCIH 2024

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.