Can You Take SAMe and 5-HTP Together?

Use extra care with this pair

The short answer

SAMe increases serotonin levels. Combining with 5-HTP significantly raises serotonin syndrome risk.

How to arrange timing

Do not combine. Risk of serotonin syndrome.

Reference

Reference noted for this combination: Examine.com 2024

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.