Can You Take 5-HTP and Methylene Blue Together?

Use extra care with this pair

The short answer

Methylene blue is a potent MAO-A inhibitor. Combining with 5-HTP (a serotonin precursor) significantly increases the risk of serotonin syndrome.

How to arrange timing

Do not combine methylene blue with 5-HTP. This combination carries a significant risk of serotonin syndrome.

Reference

Reference noted for this combination: Ramsay RR, et al. Br J Pharmacol. 2007

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.