Can You Take 5-HTP and Iboga Together?

Use extra care with this pair

The short answer

Iboga contains ibogaine, which affects serotonin transporters and has MAO-inhibiting properties. Combining with 5-HTP may significantly increase the risk of serotonin syndrome.

How to arrange timing

Do not combine Iboga with 5-HTP due to serious risk of serotonin syndrome. Seek medical guidance if considering either.

Reference

Reference noted for this combination: Glick SD, Maisonneuve IM. Ann N Y Acad Sci. 2000;909:274-287

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.