Can You Take 5-HTP and Adrafinil Together?

Use extra care with this pair

The short answer

5-HTP increases serotonin availability, and Adrafinil affects monoamine neurotransmission including serotonin. This stacking may contribute to excessive serotonergic stimulation.

How to arrange timing

Exercise caution when combining 5-HTP and Adrafinil. Start with low doses and watch for signs of serotonin excess.

Reference

Reference noted for this combination: Dvir Y, Bhatt L, Bhatt DL. Serotonin syndrome with drug combinations. Pharmacotherapy. 2008;28(6):779-790.

Important context

Whether supplements suit you together also depends on dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.