Does Tea Affect Methylfolate?

May affect absorption or how you feel

The short answer

Tea catechins may interfere with folate transporter activity, reducing methylfolate uptake even though it bypasses DHFR.

How to arrange timing

Take methylfolate at least 1 hour apart from tea.

Reference

Reference noted for this food and supplement combination: Examine.com 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.