Does Tea Affect Berberine?

Amount or timing may matter

The short answer

Tea catechins inhibit the same CYP enzymes (CYP3A4, CYP2C9) that metabolize berberine, potentially increasing berberine blood levels and GI side effects.

How to arrange timing

Separate berberine from tea by at least 2 hours.

Reference

Reference noted for this food and supplement combination: Examine.com 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.