Does Spicy foods Affect Nattokinase?

Use extra care with this combination

The short answer

Capsaicin has mild antiplatelet activity, and nattokinase is a fibrinolytic enzyme. Combined use may increase bleeding risk.

How to arrange timing

Separate nattokinase from spicy food by at least 2 hours. Monitor for unusual bruising or bleeding.

Reference

Reference noted for this food and supplement combination: NIH ODS 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.