Does Soy foods Affect Progesterone Cream?

Amount or timing may matter

The short answer

Soy isoflavones compete with progesterone at hormone receptors. High soy intake may reduce the effectiveness of topical progesterone.

How to arrange timing

Limit soy intake when using progesterone cream; discuss with your healthcare provider.

Reference

Reference noted for this food and supplement combination: Patisaul & Jefferson, Front Neuroendocrinol 2010

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.