Does Grapefruit Affect Vinpocetine?

Amount or timing may matter

The short answer

Vinpocetine is metabolized by CYP3A4. Grapefruit may increase its blood levels, potentially causing excessive vasodilation and hypotension.

How to arrange timing

Avoid grapefruit within 4 hours of vinpocetine. Watch for dizziness or lightheadedness.

Reference

Reference noted for this food and supplement combination: Examine.com; Vereczkey, Eur J Drug Metab Pharmacokinet 1985

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.