Does Grapefruit Affect Schisandra?

Amount or timing may matter

The short answer

Schisandrin B is a CYP3A4 inhibitor. Combined with grapefruit, additive CYP3A4 inhibition may dangerously elevate levels of other co-administered supplements.

How to arrange timing

Avoid combining schisandra with grapefruit, especially if taking other CYP3A4-sensitive supplements.

Reference

Reference noted for this food and supplement combination: Iwata et al., Drug Metab Dispos 2004; Examine.com

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.