Does Grapefruit Affect Pine Bark Extract?

May affect absorption or how you feel

The short answer

Pycnogenol (pine bark) contains procyanidins that modulate CYP enzymes. Grapefruit may cause additive CYP inhibition.

How to arrange timing

Separate pine bark extract from grapefruit by 2 hours.

Reference

Reference noted for this food and supplement combination: Examine.com; Takizawa et al., Biol Pharm Bull 2006

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.