Does Grapefruit Affect Kratom?

Use extra care with this combination

The short answer

Mitragynine in kratom is a CYP3A4 substrate. Grapefruit can significantly increase kratom blood levels, raising risk of respiratory depression and toxicity.

How to arrange timing

Never combine grapefruit with kratom. This is a potentially life-threatening interaction.

Reference

Reference noted for this food and supplement combination: Kamble et al., Drug Metab Dispos 2020

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.