Does Grapefruit Affect Ginkgo Biloba?

Amount or timing may matter

The short answer

Ginkgo terpenoids are CYP3A4 substrates. Grapefruit may increase ginkgolide blood levels, potentially increasing bleeding risk due to PAF antagonism.

How to arrange timing

Separate ginkgo biloba from grapefruit by at least 4 hours.

Reference

Reference noted for this food and supplement combination: Chatterjee et al., Life Sci 2005; Examine.com

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.