Does Grapefruit Affect Echinacea?

May affect absorption or how you feel

The short answer

Echinacea alkylamides are CYP3A4 substrates. Grapefruit may modestly increase echinacea blood levels.

How to arrange timing

Separate echinacea from grapefruit by 2 hours.

Reference

Reference noted for this food and supplement combination: Gorski et al., Clin Pharmacol Ther 2004

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.