Does Grapefruit Affect DHEA?

Amount or timing may matter

The short answer

DHEA is metabolized by CYP3A4. Grapefruit may increase DHEA blood levels, potentially increasing hormonal side effects (acne, hair growth, mood changes).

How to arrange timing

Avoid grapefruit within 4 hours of taking DHEA supplements.

Reference

Reference noted for this food and supplement combination: Examine.com; Prough et al., Front Pharmacol 2016

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.