Does Grapefruit Affect Danshen (Salvia miltiorrhiza)?

Amount or timing may matter

The short answer

Tanshinones in danshen are CYP3A4 substrates. Grapefruit may increase their blood levels, raising bleeding risk due to enhanced antiplatelet activity.

How to arrange timing

Separate danshen from grapefruit by at least 4 hours. Watch for unusual bruising or bleeding.

Reference

Reference noted for this food and supplement combination: Yu et al., Phytomedicine 2014

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.