Does Grapefruit Affect Artemisinin?

Use extra care with this combination

The short answer

Artemisinin is a CYP3A4 substrate with a narrow therapeutic window. Grapefruit significantly increases its blood levels, risking neurotoxicity.

How to arrange timing

Avoid grapefruit entirely while taking artemisinin supplements.

Reference

Reference noted for this food and supplement combination: Svensson & Ashton, Clin Pharmacol Ther 1999

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.