Does Grapefruit Affect Adrafinil?

Amount or timing may matter

The short answer

Adrafinil is a prodrug converted to modafinil via CYP3A4. Grapefruit may alter this conversion and increase active metabolite levels.

How to arrange timing

Avoid grapefruit within 4 hours of adrafinil. Increased liver stress risk.

Reference

Reference noted for this food and supplement combination: Examine.com; Milgram et al., Neurobiol Aging 2000

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.