Does Dairy Affect Doxycycline (Low Dose)?

Amount or timing may matter

The short answer

Calcium in dairy chelates doxycycline, forming insoluble complexes that can reduce absorption by up to 50%. This is a well-established clinical interaction.

How to arrange timing

Never take doxycycline with dairy. Separate by at least 2 hours.

Reference

Reference noted for this food and supplement combination: FDA

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.