Does Caffeine Affect Yohimbine?

Use extra care with this combination

The short answer

Both caffeine and yohimbine increase sympathetic nervous system activity. Combined use may cause severe hypertension, anxiety, and panic attacks.

How to arrange timing

Avoid combining yohimbine with caffeine. The cardiovascular risk is significant.

Reference

Reference noted for this food and supplement combination: Examine.com 2024; FDA safety alert

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.