Does Caffeine Affect Synephrine?

Use extra care with this combination

The short answer

Synephrine combined with caffeine significantly increases heart rate and blood pressure. This combination poses cardiovascular risk.

How to arrange timing

Avoid combining synephrine with caffeine. Monitor blood pressure if unavoidable.

Reference

Reference noted for this food and supplement combination: EFSA 2015; Stohs et al. 2012

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.