Does Caffeine Affect Skullcap?

Amount or timing may matter

The short answer

Skullcap (Scutellaria) has GABA-A receptor binding activity for anxiolytic effects. Caffeine's stimulant mechanism directly counteracts this.

How to arrange timing

Separate skullcap from caffeine by at least 4 hours.

Reference

Reference noted for this food and supplement combination: Examine.com 2024; Awad et al. 2003

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.