Does Caffeine Affect Phosphatidylserine?

May affect absorption or how you feel

The short answer

Phosphatidylserine blunts caffeine-induced cortisol spikes. While not harmful, concurrent use may reduce PS's cortisol-lowering benefit.

How to arrange timing

Can be taken together; PS may help offset caffeine's cortisol elevation.

Reference

Reference noted for this food and supplement combination: Monteleone et al. 1992; Examine.com

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.