Does Caffeine Affect Ephedra?

Use extra care with this combination

The short answer

Ma huang (ephedra) combined with caffeine dramatically increases cardiovascular risk including heart attack, stroke, and sudden death.

How to arrange timing

Never combine ma huang with caffeine. This is one of the most dangerous supplement-stimulant combinations.

Reference

Reference noted for this food and supplement combination: FDA 2004 ban; Haller & Benowitz 2000

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.