Does Caffeine Affect Lithium Orotate?

Amount or timing may matter

The short answer

Caffeine's diuretic effect increases renal lithium clearance, potentially reducing lithium's therapeutic levels unpredictably.

How to arrange timing

Maintain consistent caffeine intake when taking lithium. Sudden changes can alter lithium levels.

Reference

Reference noted for this food and supplement combination: Examine.com 2024; Grandjean et al. 1977

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.