Does Caffeine Affect Lemon Balm?

Amount or timing may matter

The short answer

Lemon balm inhibits GABA transaminase to increase GABA levels. Caffeine opposes this calming effect through CNS stimulation.

How to arrange timing

Separate lemon balm from caffeine by at least 4 hours when using for relaxation.

Reference

Reference noted for this food and supplement combination: Examine.com 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.