Does Caffeine Affect CBD (Cannabidiol)?

May affect absorption or how you feel

The short answer

CBD has calming and anxiolytic properties. Caffeine may diminish CBD's relaxation effects. Both are CYP1A2 substrates, potentially altering metabolism of each other.

How to arrange timing

Separate CBD from caffeine by 2 hours. Monitor for altered effects of both.

Reference

Reference noted for this food and supplement combination: Examine.com 2024; Nasrin et al. 2021

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.