Does Caffeine Affect Berberine?

May affect absorption or how you feel

The short answer

Caffeine stimulates gastric acid secretion which may degrade berberine. Both also affect blood glucose levels, potentially causing unpredictable glycemic effects.

How to arrange timing

Separate berberine from caffeine by 2 hours to protect absorption.

Reference

Reference noted for this food and supplement combination: Examine.com 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.