Does Alcohol Affect St. John's Wort?

Use extra care with this combination

The short answer

St. John's wort combined with alcohol causes excessive CNS depression. St. John's wort also induces CYP2E1, altering alcohol metabolism unpredictably.

How to arrange timing

Never combine St. John's wort with alcohol.

Reference

Reference noted for this food and supplement combination: NIH NCCIH 2024; FDA

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.