Does Alcohol Affect SAMe?

Amount or timing may matter

The short answer

Alcohol depletes SAMe and impairs the methylation cycle that SAMe supports. It significantly reduces SAMe's liver-protective benefits.

How to arrange timing

Avoid alcohol while supplementing with SAMe, especially for liver support.

Reference

Reference noted for this food and supplement combination: Examine.com 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.