Does Alcohol Affect Retinyl Palmitate?

Use extra care with this combination

The short answer

Retinyl palmitate is a preformed vitamin A ester. Combined with alcohol, it poses serious hepatotoxicity risk via CYP2E1-mediated toxic metabolite formation.

How to arrange timing

Avoid alcohol entirely on days you take retinyl palmitate.

Reference

Reference noted for this food and supplement combination: FDA; NIH ODS 2024

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.