Does Alcohol Affect Metformin (Off-label)?

Use extra care with this combination

The short answer

Both alcohol and metformin can cause lactic acidosis. Combined use significantly increases this life-threatening risk and stresses the liver.

How to arrange timing

Avoid alcohol entirely when taking metformin. Risk of fatal lactic acidosis.

Reference

Reference noted for this food and supplement combination: FDA Black Box Warning

Important context

The effect can also change with food amount, supplement dose, product formulation, health conditions, and medication use. Ask a doctor or pharmacist first if you take medication, are pregnant or breastfeeding, or have a chronic condition.